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Biological sequences, chromosome, cross chromosomal similarity, compression gain, prediction

While modern hardware can provide vast amounts of inexpensive storage for biological databases, the compression of Biological sequences is still of paramount importance in order to facilitate fast search and retrieval operations through a reduction in disk traffic. This issue becomes even more important in light of the recent increase of very large data sets, such as meta genomes. The present Biological sequence compression algorithms work by finding similar repeated regions within the Biological sequence and then encode these repeated regions together for compression. The previous research on chromosome sequence similarity reveals that the length of similar repeated regions within one chromosome is about 4.5% of the total sequence length. The compression gain is often not high because of these short lengths of repeated regions. It is well recognized that similarities exist among different regions of chromosome sequences. This implies that similar repeated sequences are found among different regions of chromosome sequences. Here, we apply cross-chromosomal similarity for a Biological sequence compression. The length and location of similar repeated regions among the different Biological sequences are studied. It is found that the average percentage of similar subsequences found between two chromosome sequences is about 10% in which 8% comes from cross-chromosomal prediction and 2% from self-chromosomal prediction. The percentage of similar subsequences is about 18% in which only 1.2% comes from self-chromosomal prediction while the rest is from cross-chromosomal prediction among the different Biological sequences studied. This suggests the significance of cross-chromosomal similarities in addition to self-chromosomal similarities in the Biological sequence compression. An additional 23% of storage space could be reduced on average using self-chromosomal and cross-chromosomal predictions in compressing the different Biological sequences.