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Development of on Chip Devices for Life Science Applications
Stephanus Buttgenbach, Anne Balck, Stefanie Demming, Claudia Lesche, Monika Michalzik, Alaaldeen
Pages - 148 - 158 | Revised - 05-05-2009 | Published - 18-05-2009
Published in International Journal of Engineering (IJE)
MORE INFORMATION
KEYWORDS
Microfluidics, Biosensors, Bioreactors, micropumps
ABSTRACT
This work reports on diverse technologies implemented for fabricating microfluidic devices such as biomedical micro sensors, micro pumps, bioreactors and micro separators. UV depth lithography and soft lithography were applied in the fabrication processes using different materials, for example SU-8, polydimethylsiloxane (PDMS), silicon, glass and ceramics. Descriptions of the fabrication process of completed devices and their performance are provided. Experimental tests and results are presented where available.
This work highlights the importance of down scaling in producing efficient devices suitable for life science applications using diverse materials that are compatible with chemical and biomedical applications.
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2 | Gothsch, T., Richter, C., Beinert, S., Schilcher, C., Schilde, C., Büttgenbach, S., & Kwade, A. (2016). Effect of cavitation on dispersion and emulsification process in high-pressure microsystems (HPMS). Chemical Engineering Science, 144, 239-248. |
3 | Gothsch, T., Schilcher, C., Richter, C., Beinert, S., Dietzel, A., Büttgenbach, S., & Kwade, A. (2015). High-pressure microfluidic systems (HPMS): flow and cavitation measurements in supported silicon microsystems. Microfluidics and Nanofluidics, 18(1), 121-130. |
4 | Al-Halhouli, A. A., Demming, S., Alahmad, L., LIobera, A., & Büttgenbach, S. (2014). An in-line photonic biosensor for monitoring of glucose concentrations. Sensors, 14(9), 15749-15759. |
5 | Al-Halabi, L., Balck, A., Michalzik, M., Fröde, D., Büttgenbach, S., Hust, M., ... & Dübel, S. (2013, January). Recombinant antibody fragments allow repeated measurements of C-reactive protein with a quartz crystal microbalance immunosensor. In MAbs (Vol. 5, No. 1, pp. 140-149). Taylor & Francis. |
6 | Lorenz, T., Al-Halhouli, A. T., Mohsen, M., Matar, M., Büttgenbach, S., & Dietzel, A. (2013). Entwicklung und Simulation passiver Mikromischer für Strömungen im Bereich niedriger Reynolds-Zahlen. Mikrosystemtechnik 2013. |
7 | Boese, C., Dietzel, A., & Büttgenbach, S. (2013). Multifunktionaler Werkzeugwechsler für den Einsatz in mikrotechnischen Prozessketten–Messen, Prüfen, Montieren. Mikrosystemtechnik 2013. |
8 | A.B. Mattos, T.A. Freitas, V.L. Silva, R.F. Dutra, “A Dual Quartz Crystal Microbalance For Human Cardiac Troponin T In Real Time Detection”, Sensors and Actuators B: Chemical, 161(1), pp. 439–446, January 2012. |
9 | Bu¨ttgenbach, S. (2010, January). Numerical Analysis of Mixing in a Multifunction Electromagnetic Micropump. In ASME 2010 8th International Conference on Nanochannels, Microchannels, and Minichannels collocated with 3rd Joint US-European Fluids Engineering Summer Meeting (pp. 1299-1302). American Society of Mechanical Engineers. |
10 | Al-Halhouli, A. T. (2010, February). Analysis on the effect of geometrical design parameters on maximum shear stresses in an electromagnetic micropump. In MOEMS-MEMS (pp. 759315-759315). International Society for Optics and Photonics. |
11 | A. T. Al-Halhouli, A. Waldschik, M. I. Kilani, S. Büttgenbach: “Gentle Micropump Based on Microelectromagnetic Actuator” NSTI Nanotech, 2(2010), pp. 340-343, June 2010. |
12 | Al-Halhouli, A. A. T. (2009). Recent advances in on-disk viscous micropumps. Journal of Microelectronics and Electronic Packaging, 6(4), 240-249. |
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12. M. Feldmann, S. Demming, C. Lesche, S. Büttgenbach. “Novel Electromagnetic micropump”. Proceedings of SPIE, 2007. | |
13. R. Wilke, S. Büttgenbach. “A micromachined capillary electrophoresis chip with fully integrated electrodes for separation and electrochemical detection”. Biosensors and Bioelectronics, 19:149-153, 2003. | |
14. S. Demming, A. Jansen, E. Franco-Lara, R. Krull, S. Büttgenbach. “Mikroreaktorsystem als Screening-instrument für biologische Prozesse“. Proceedings of MicroSystemTechnology Congress, Dresden, 2007. | |
15. A. Edlich, S. Demming, M. Vogl, S. Büttgenbach, E. Franco-Lara, R. Krull. “Microfluidic Screening Reactor for Estimation of Biological Reaction Kinetics”. Proceedings of 1st European Congress on Microfluidics, Bologna, 2008. | |
16. J. M. Gancedo. “Control of pseudohyphae formation in Saccharomyces cerevisiae”. FEMS Microbiology Reviews, 25:107-123, 2001. | |
17. M. Michalzik, A. Balck, S. Büttgenbach, L. Al-Halabi, M. Hust, S: Dübel. “Microsensor System for Biochemical and Medical Analysis”, Proc. XX Eurosensors, Göteborg, 2006. | |
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20. A. Balck, M. Michalzik, M. Wolff, U. Reichl, S. Büttgenbach. “Influenza virus detection in vaccine production with a quartz crystal microbalance”. Proceedings of Biosensors 2008, Shanghai, 2008. | |
21. M. Michalzik, L. Al-Halabi, A. Balck, M. Hust, S: Dübel, S. Büttgenbach. “A mass sensitivemicrofluidic immunosensor for CRP-detection using functional monolayers”. Proceedings of Biosensors 2008, Shanghai, 2008a. | |
22. M. Michalzik, A. Balck, L. Al-Halabi, M. Hust, S: Dübel, S. Büttgenbach. “Massensensitives Sensor-Fließsystem zur CRP-Diagnostik”. Proceedings of. Mikrosystemtechnikkongress, Dresden, 2007. | |
23. J. Rabe, S. Büttgenbach, B. Zimmermann, P. Hauptmann. Proceedings of IEEE/EIA International Frequency Control Symposium 2000. | |
24. A. Balck, A. T. Al-Halhouli, S. Büttgenbach. “Separation of blood cells in Y- microchannels”. ICTEA09, Abu Dhabi, 2009. | |
25. A. Majid. “Electrostatic and Electromagnetic fields actuators for MEMS AD/DA converters” International Journal of Engineering, 2(1):35-41, 2007. | |
26. M. Michalzik, A. Balck, C. Ayala, N. Lucas, S. Demming, A. Phataralaoha, S. Büttgenbach. “A Hydrogel-Actuated Microvalve for Medical and Biochemical Sensing”. Actuator 08, Bremen, 2008b. | |
27. V. C. Ayala, M. Michalzik, S. Harling, H. Menzel, F. A. Guarnieri, S. Büttgenbach. “Design, Construction and Testing of a Monolithic pH-Sensitive Hydrogel-Valve for Biochemical and Medical Application”. Journal of Physics, Conference Series 90, 2007. | |
4. B. Hoxhold, M. Kirchhoff, S. Bütefisch, S. Büttgenbach. “SMA Driven Micro Grippers Combining Piezo-Resistive Gripping Force Sensors with Epon SU-8 Mechanics”. XX Eurosensors 2006, Göteborg, 2006. | |
5. H. Sato, H. Matsumura, S. Keino, S. Shoji. “An all SU-8 microfluidic chip with built-in 3D fine microstructures”. J. Micromech. Microeng. 16:2318-2322, 2006. | |
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7. A. Al-Halhouli, I. Kampen, T. Krah, S. Büttgenbach. “Nanoindentation testing of SU-8 photoresist mechanical properties”. Microelectronic Engineering, 85:942-944, 2008. | |
8. M. Feldmann, A. Waldschik, S. Büttgenbach. “A novel fabrication process for 3D-multilayer micro mixers”. Proc. 8th Int. Conf. on Miniaturized Systems for Chemistry and Life Sciences. Malmö, 2004. | |
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M. Al-Shurman, S-M. Yoo, and S. Park, “Black Hole Attack in Mobile Ad Hoc Networks,” ACM Southeast Regional Conf. 2004. | |
V. Srinivasan, V. Pamula, R. Fair. “An Integrated digital microfluidic lab-on-a-chip for clinical diagnostics on human physiological fluids”. Lab on a Chip, 4:310-315, 2004. | |
Professor Stephanus Buttgenbach
- Germany
Mr. Anne Balck
- Germany
Miss Stefanie Demming
- Germany
Miss Claudia Lesche
- Germany
Dr. Monika Michalzik
- Germany
Mr. Alaaldeen
- Germany
ala_t25@yahoo.com
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